NKX2-1

Across TCGA patient cohorts, NKX2-1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,066 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NKX2-1-associated proteins across cancer lineages are SNTB1_T214, CADM1, and CLDN3_S209. Each is linked with NKX2-1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NKX2-1-to-partner and partner-to-NKX2-1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NKX2-1 versus SNTB1_T214 in LSCC, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-1→partner) and Y-score (partner→NKX2-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SNTB1_T214 →	+0.447	+1.311	<.001	<.001	3	3
LSCC	CADM1 →	+0.552	+1.318	<.001	.001	3	3
HNSC	CLDN3_S209 →	+1.518	+0.763	<.001	<.001	3	3
LUAD	DDAH1 →	+0.526	+1.113	.002	.001	3	3
LSCC	IREB2 →	-0.253	-1.141	.004	<.001	3	3
LUAD	LAPTM4A →	+1.271	+1.135	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,066 associations by consensus.

NKX2-1 vs SNTB1_T214 — LSCC

Explore this scatter interactively →