NKX2-1

Across TCGA patient cohorts, NKX2-1 mutation is significantly associated with the RNA expression of many other genes, with 1,206 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKX2-1-associated genes across cancer lineages are ABHD3, TLCD3A, and TNK1. Each is linked with NKX2-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX2-1-to-partner and partner-to-NKX2-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ABHD3 grouped by NKX2-1-low versus NKX2-1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-1→partner) and Y-score (partner→NKX2-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ABHD3 →	+0.630	+3.491	.004	.002	3	2
UCEC	TLCD3A →	+0.594	+3.362	.008	.005	3	2
UCEC	TNK1 →	+0.544	+4.098	.002	<.001	3	2
UCEC	TOP3A →	+0.441	+3.375	.003	.004	3	2
UCEC	HASPIN →	+0.801	+3.606	<.001	.001	3	2
UCEC	RAD51 →	+0.784	+3.010	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,206 associations by consensus.

ABHD3 by NKX2-1 expression — UCEC

Explore this box plot interactively →