NKX2-1

Across TCGA patient cohorts, NKX2-1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKX2-1-associated genes across cancer lineages are Caspase-7-cleavedD198, Src, and Myosin-IIa. Each is linked with NKX2-1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NKX2-1-to-partner and partner-to-NKX2-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by NKX2-1-low versus NKX2-1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-1→partner) and Y-score (partner→NKX2-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.476	+2.815	<.001	.036	3	3
UCEC	Src →	+0.217	+3.026	.029	.018	3	2
UCEC	Myosin-IIa →	+0.203	+2.177	.037	.035	3	1
UCEC	p62 Lck ligand →	+0.324	+2.459	.039	.020	2	2
UCEC	Annexin-1 →	+0.677	+3.189	.007	.010	3	1
UCEC	VHL →	-0.967	-3.321	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Caspase-7-cleavedD198 by NKX2-1 expression — COAD

Explore this box plot interactively →