NKX2-1

Across TCGA cell cohorts, NKX2-1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,175 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible NKX2-1-associated GO terms across cancer lineages are Globus pallidus development, Spliceosomal conformational changes to generate catalytic conformation, and Nucleic acid catabolic process. Each is linked with NKX2-1 in more than 12 cancer types. Because this analysis shows association rather than direction, both NKX2-1-to-partner and partner-to-NKX2-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Globus pallidus development grouped by NKX2-1-low versus NKX2-1-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-1→partner) and Y-score (partner→NKX2-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Globus pallidus development →	+1.994	+4.507	<.001	<.001	3	13
OESOPHAGUS	Spliceosomal conformational changes to generate catalytic conformation →	+0.110	+1.407	.004	.009	3	9
OESOPHAGUS	Nucleic acid catabolic process →	+0.087	+1.766	<.001	<.001	3	8
LUNG_SCLC	Regulation of RNA splicing →	+0.062	+3.296	.003	.001	3	8
LUNG_SCLC	Protein K11-linked ubiquitination →	+0.068	+3.085	.001	.002	2	9
LUNG_NSCLC_LUAD	Regulation of DNA-templated transcription elongation →	+0.029	+2.110	.001	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,175 associations by consensus.

Globus pallidus development by NKX2-1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →