NKX2-1

Across TCGA cell cohorts, NKX2-1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NKX2-1-associated genes across cancer lineages are CCDC195, MS4A4A, and MSGN1. Each is linked with NKX2-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX2-1-to-partner and partner-to-NKX2-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC195 grouped by NKX2-1-low versus NKX2-1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-1→partner) and Y-score (partner→NKX2-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CCDC195 →	+0.044	+4.887	<.001	.009	3	1
LARGE_INTESTINE	MS4A4A →	+0.139	+3.678	<.001	.009	3	1
LARGE_INTESTINE	MSGN1 →	+0.100	+3.930	<.001	.003	3	1
LARGE_INTESTINE	CLPSL1 →	+0.134	+4.054	<.001	.004	3	1
LARGE_INTESTINE	KRTAP10-3 →	+0.043	+3.920	<.001	.005	3	1
LARGE_INTESTINE	RNF212B →	+0.146	+3.678	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

CCDC195 by NKX2-1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →