Across TCGA patient cohorts, NKX1-2 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKX1-2-associated genes across cancer lineages are RNU6-992P, RNU6-1155P, and RNU4-13P. Each is linked with NKX1-2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX1-2-to-partner and partner-to-NKX1-2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX1-2→partner) and Y-score (partner→NKX1-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-992P →	+0.184	+4.292	<.001	.006	3	1
UCEC	RNU6-1155P →	+0.221	+5.475	<.001	.001	3	1
UCEC	RNU4-13P →	+0.191	+4.464	<.001	.005	3	1
UCEC	RNU6-1264P →	+0.270	+4.660	<.001	.003	3	1
UCEC	MIR629 →	+0.313	+3.997	<.001	.009	3	1
UCEC	CCL27 →	+0.056	+4.885	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration

NKX1-2 survival (RNA) · tumor vs normal (RNA) · all NKX1-2 data types