Across TCGA pan-cancer cohorts, NKX1-2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated NKX1-2 data layer.
The strongest signal is observed in colon adenocarcinoma (COAD), where higher NKX1-2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NKX1-2 expression acts as an unfavorable survival marker, although some lineages such as CESC and LGG show a favorable association.
COAD, CESC, and UCEC are the cancer types where NKX1-2 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.