NKX1-2

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, NKX1-2 mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKX1-2-associated genes across cancer lineages are TIGAR and p62 Lck ligand. Each is linked with NKX1-2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX1-2-to-partner and partner-to-NKX1-2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX1-2→partner) and Y-score (partner→NKX1-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECTIGAR →+0.232+2.833.013.03531
UCECp62 Lck ligand →+0.565+2.817.004.03621
Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

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