NKX1-1

Across TCGA patient cohorts, NKX1-1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,183 significant associations in total. STAD shows the largest number of these associations.

The most reproducible NKX1-1-associated GO terms across cancer lineages are ATP biosynthetic process, Protein localization to mitochondrion, and Virion assembly. Each is linked with NKX1-1 in more than 6 cancer types. Because this analysis shows association rather than direction, both NKX1-1-to-partner and partner-to-NKX1-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP biosynthetic process grouped by NKX1-1-low versus NKX1-1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX1-1→partner) and Y-score (partner→NKX1-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ATP biosynthetic process →	+0.073	+0.047	<.001	<.001	3	6
STAD	Protein localization to mitochondrion →	+0.058	+0.028	<.001	<.001	3	6
STAD	Virion assembly →	+0.047	+0.044	<.001	.001	3	6
STAD	Negative regulation of protein ubiquitination →	+0.055	+0.027	<.001	<.001	3	6
STAD	ATP synthesis coupled electron transport →	+0.079	+0.027	<.001	<.001	3	6
STAD	Cellular respiration →	+0.071	+0.027	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,183 associations by consensus.

ATP biosynthetic process by NKX1-1 expression — STAD

Explore this box plot interactively →