NKX1-1

Across TCGA pan-cancer cohorts, NKX1-1 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of NKX1-1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where NKX1-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NKX1-1 is over-expressed in tumor.

LIHC are the cancer types where NKX1-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NKX1-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	All	+0.042	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

NKX1-1–LIHC

Open the LIHC breakdown →