NKX1-1

Across TCGA pan-cancer cohorts, NKX1-1 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated NKX1-1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher NKX1-1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NKX1-1 expression acts as an unfavorable survival marker.

ACC, UCS, and KICH are the cancer types where NKX1-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.116	0.706	<.001	72	view →
UCS	OS	Tertile	III,IV	0.104	0.591	.004	72	view →
KICH	DFS	Tertile	II,III,IV	0.035	0.860	<.001	63	view →
STAD	DFS	Tertile	III,IV	0.440	0.618	.015	45	view →
CESC	OS	Tertile	IV	0.121	0.591	.029	36	view →
LIHC	DFS	Tertile	All	0.220	0.465	.002	33	view →
BLCA	OS	Tertile	IV	0.082	0.575	.002	18	view →
KIRC	DFS	Tertile	IV	0.243	0.642	.012	18	view →
SARC	OS	Tertile	All	0.242	0.632	<.001	18	view →
SKCM	OS	Tertile	IV	0.415	0.861	.014	9	view →
COAD	OS	Tertile	All	0.329	0.595	.025	9	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

NKX1-1–ACC (OS)

Open the ACC breakdown →