NKX1-1

Across TCGA cell cohorts, NKX1-1 RNA expression is significantly associated with the mutation status of many other genes, with 5 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible NKX1-1-associated genes across cancer lineages are MDN1, SERAC1, and ST6GAL2. Each is linked with NKX1-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX1-1-to-partner and partner-to-NKX1-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MDN1 grouped by NKX1-1-low versus NKX1-1-high in SOFT_TISSUE.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX1-1→partner) and Y-score (partner→NKX1-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MDN1 →	+3.515	+0.039	.003	<.001	3	1
SOFT_TISSUE	SERAC1 →	+4.930	+0.078	.008	<.001	3	1
LUNG_SCLC	ST6GAL2 →	+3.584	+0.060	.003	.009	3	1
LUNG_SCLC	C2CD3 →	+3.169	+0.081	.005	<.001	3	1
LUNG_SCLC	TRIM49 →	+4.169	+0.073	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MDN1 by NKX1-1 expression — SOFT_TISSUE

Explore this box plot interactively →