NKX1-1

Across TCGA cell cohorts, NKX1-1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NKX1-1-associated genes across cancer lineages are TAS2R7, MMP27, and KRTAP12-3. Each is linked with NKX1-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX1-1-to-partner and partner-to-NKX1-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAS2R7 grouped by NKX1-1-low versus NKX1-1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX1-1→partner) and Y-score (partner→NKX1-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TAS2R7 →	+0.014	+4.437	<.001	.004	3	2
BLOOD_Leukemia	MMP27 →	+0.026	+5.969	<.001	.001	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.082	+5.539	<.001	.003	3	1
BREAST	OR1L1 →	+0.036	+5.169	<.001	.005	3	1
LARGE_INTESTINE	COX6A2 →	+0.082	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR1L6 →	+0.022	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

TAS2R7 by NKX1-1 expression — LARGE_INTESTINE

Explore this box plot interactively →