NKTR

Across TCGA patient cohorts, NKTR mutation is significantly associated with the RNA expression of many other genes, with 2,717 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKTR-associated genes across cancer lineages are RN7SL810P, MIR153-1, and PCNPP4. Each is linked with NKTR in more than 3 cancer types. Because this analysis shows association rather than direction, both NKTR-to-partner and partner-to-NKTR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL810P grouped by NKTR-low versus NKTR-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKTR→partner) and Y-score (partner→NKTR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SL810P →	+0.197	+5.009	<.001	<.001	3	4
LUSC	MIR153-1 →	+0.415	+4.370	<.001	.002	3	2
LUSC	PCNPP4 →	+0.119	+3.815	<.001	.007	3	2
LUSC	OR12D1 →	+0.308	+4.853	<.001	.004	3	2
CESC	RN7SKP263 →	+0.060	+3.984	<.001	.009	3	2
UCEC	YTHDF3-AS1 →	+0.500	+1.748	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,717 associations by consensus.

RN7SL810P by NKTR expression — HNSC

Explore this box plot interactively →