NKG7

Across TCGA patient cohorts, NKG7 mutation is significantly associated with the RNA expression of many other genes, with 142 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKG7-associated genes across cancer lineages are OR5AN2P, TXNL4AP1, and SOCS6P1. Each is linked with NKG7 in more than 2 cancer types. Because this analysis shows association rather than direction, both NKG7-to-partner and partner-to-NKG7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5AN2P grouped by NKG7-low versus NKG7-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKG7→partner) and Y-score (partner→NKG7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR5AN2P →	+0.028	+4.814	<.001	.003	3	3
COAD	TXNL4AP1 →	+0.313	+4.951	<.001	.002	3	2
UCEC	SOCS6P1 →	+0.106	+4.253	<.001	<.001	3	2
UCEC	RPL35AP7 →	+0.457	+3.699	.008	.002	3	2
UCEC	COPS8P1 →	+0.140	+2.842	<.001	.007	3	1
UCEC	RNA5SP412 →	+0.791	+3.289	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 142 associations by consensus.

OR5AN2P by NKG7 expression — BLCA

Explore this box plot interactively →