NKG7

Across TCGA pan-cancer cohorts, NKG7 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of NKG7’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NKG7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NKG7 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, LUAD, and LUSC are the cancer types where NKG7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NKG7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+3.421	<.001	12	view →
LUAD	Female	II,III,IV	−1.679	<.001	9	view →
LUSC	Male	II,III,IV	−2.062	<.001	8	view →
KIRP	Male	All	+1.300	.001	6	view →
ESCA	All	All	+1.434	.016	4	view →
STAD	All	II,III,IV	+1.138	.044	2	view →
UCEC	All	All	−0.850	.028	2	view →
BRCA	All	II,III,IV	−0.352	.041	2	view →
LIHC	Male	All	−0.722	.008	1	view →
COAD	All	All	−0.625	.010	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

NKG7–KIRC

Open the KIRC breakdown →