NKD1

Across TCGA patient cohorts, NKD1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKD1-associated genes across cancer lineages are VEGFR2, ATM, and EGFR_pY1068. Each is linked with NKD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKD1-to-partner and partner-to-NKD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VEGFR2 grouped by NKD1-low versus NKD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKD1→partner) and Y-score (partner→NKD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VEGFR2 →	+0.322	+3.331	.013	.005	3	2
UCEC	ATM →	-0.475	-2.115	.016	.019	3	2
UCEC	EGFR_pY1068 →	-0.241	-2.115	.028	.019	3	1
UCEC	Gab2 →	+0.414	+2.807	.007	.003	3	1
UCEC	Ku80 →	+0.290	+2.331	.004	.019	3	1
UCEC	MEK1 →	+0.422	+3.459	.008	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

VEGFR2 by NKD1 expression — UCEC

Explore this box plot interactively →