NKD1

Across TCGA pan-cancer cohorts, NKD1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of NKD1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NKD1 RNA is repressed in tumor relative to normal tissue. In most cancer types NKD1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, COAD, and KICH are the cancer types where NKD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NKD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−1.328	<.001	12	view →
COAD	All	IV	+4.061	<.001	11	view →
KICH	Male	II,III,IV	−1.432	<.001	11	view →
HNSC	All	All	+0.511	<.001	10	view →
LUAD	All	III,IV	−1.786	<.001	9	view →
KIRP	Male	All	−1.219	<.001	9	view →
LUSC	Female	II,III,IV	−2.221	<.001	8	view →
LIHC	All	II,III,IV	+1.892	<.001	6	view →
BLCA	Male	All	−1.050	.002	6	view →
READ	All	All	+3.077	.003	2	view →
UCEC	All	IV	−2.139	.043	2	view →
PRAD	All	All	−0.481	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

NKD1–KIRC

Open the KIRC breakdown →