NKD1

Across TCGA pan-cancer cohorts, NKD1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated NKD1 data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher NKD1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NKD1 expression acts as an unfavorable survival marker, although some lineages such as UCS and SCLC show a favorable association.

KIRP, UCS, and ACC are the cancer types where NKD1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	0.323	0.711	.001	94	view →
UCS	DFS	Median	III,IV	0.590	0.252	.002	66	view →
ACC	DFS	Quartile	All	0.198	0.706	<.001	40	view →
SCLC	OS	Quartile	III,IV	0.945	0.352	<.001	38	view →
LGG	OS	Quartile	All	0.581	0.309	<.001	35	view →
LUSC	DFS	Median	III,IV	0.200	0.840	.001	32	view →
BRCA	DFS	Tertile	II,III,IV	0.435	0.571	.016	28	view →
CESC	DFS	Quartile	All	0.752	0.908	.002	24	view →
ESCA	OS	Tertile	II,III,IV	0.624	0.399	.015	19	view →
THCA	OS	Quartile	All	0.978	1.000	.020	19	view →
LUAD	OS	Quartile	All	0.538	0.271	.003	18	view →
UVM	OS	Tertile	III,IV	0.686	0.923	.010	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

NKD1–KIRP (DFS)

Open the KIRP breakdown →