NKD1

Across TCGA cell cohorts, NKD1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NKD1-associated genes across cancer lineages are OR1E3, C1orf189, and ADAM7. Each is linked with NKD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKD1-to-partner and partner-to-NKD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1E3 grouped by NKD1-low versus NKD1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKD1→partner) and Y-score (partner→NKD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR1E3 →	+0.187	+4.285	<.001	.007	3	1
LARGE_INTESTINE	C1orf189 →	+0.160	+4.376	<.001	<.001	3	1
LARGE_INTESTINE	ADAM7 →	+0.004	+3.345	<.001	.007	3	1
LARGE_INTESTINE	CCDC168 →	+0.037	+3.878	<.001	.003	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR1E3 by NKD1 expression — STOMACH

Explore this box plot interactively →