NIPA1

Across TCGA patient cohorts, NIPA1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NIPA1-associated genes across cancer lineages are MEK1, MSH2, and p21. Each is linked with NIPA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NIPA1-to-partner and partner-to-NIPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by NIPA1-low versus NIPA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPA1→partner) and Y-score (partner→NIPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.717	+3.584	<.001	.002	3	1
UCEC	MSH2 →	-0.315	-2.973	.004	.035	3	1
UCEC	p21 →	+0.289	+2.820	.001	.035	3	1
UCEC	p62 Lck ligand →	+0.428	+2.999	.006	.035	3	1
UCEC	PDCD4 →	-0.713	-3.312	.001	.010	3	1
UCEC	PEA-15_pS116 →	+0.438	+3.169	.009	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

MEK1 by NIPA1 expression — UCEC

Explore this box plot interactively →