NIPA1

Across TCGA pan-cancer cohorts, NIPA1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of NIPA1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NIPA1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NIPA1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where NIPA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NIPA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.432	<.001	12	view →
COAD	Male	IV	+0.803	<.001	10	view →
LIHC	All	III,IV	+0.983	<.001	9	view →
STAD	All	II,III,IV	+0.824	<.001	9	view →
BLCA	Male	All	+0.927	<.001	6	view →
KIRP	Female	II,III,IV	+0.648	.002	6	view →
BRCA	All	II,III,IV	+0.497	<.001	6	view →
CHOL	Female	All	+3.356	<.001	5	view →
LUSC	Male	II,III,IV	+0.703	<.001	5	view →
KICH	Female	All	+0.622	.007	4	view →
LUAD	Male	II,III,IV	+0.560	.018	3	view →
THCA	Male	II,III,IV	−0.497	.007	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

NIPA1–HNSC

Open the HNSC breakdown →