NIPA1

Across TCGA pan-cancer cohorts, NIPA1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated NIPA1 data layer compared with 4 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher NIPA1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NIPA1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCEC show a favorable association.

MESO, LIHC, and UVM are the cancer types where NIPA1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	IV	0.172	0.485	.002	59	view →
LIHC	DFS	Tertile	All	0.433	0.603	.001	43	view →
UVM	DFS	Median	III,IV	0.333	0.762	<.001	41	view →
BLCA	DFS	Quartile	All	0.282	0.482	.002	38	view →
KIRC	DFS	Quartile	IV	0.652	0.204	.011	35	view →
CESC	DFS	Quartile	III,IV	0.694	1.000	.012	28	view →
LAML	DFS	Median	All	0.490	0.649	.007	26	view →
THCA	OS	Median	All	0.963	1.000	.012	20	view →
KICH	DFS	Quartile	II,III,IV	0.472	0.927	.006	19	view →
LUAD	OS	Quartile	All	0.221	0.607	<.001	19	view →
ACC	DFS	Median	All	0.270	0.607	.002	19	view →
KIRP	DFS	Tertile	All	0.867	0.949	.017	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

NIPA1–MESO (DFS)

Open the MESO breakdown →