NIPA1

Across TCGA cell cohorts, NIPA1 mutation is significantly associated with the drug of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NIPA1-associated genes across cancer lineages are VE-822, GSK2276186C, and 630600. Each is linked with NIPA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NIPA1-to-partner and partner-to-NIPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VE-822 grouped by NIPA1-low versus NIPA1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPA1→partner) and Y-score (partner→NIPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VE-822 →	+0.599	+2.646	.036	.047	3	1
LARGE_INTESTINE	GSK2276186C →	+0.533	+2.649	.020	.046	3	1
LARGE_INTESTINE	630600 →	+0.690	+2.649	.026	.046	3	1
LARGE_INTESTINE	AT7867 →	+0.571	+2.652	.016	.045	2	1
LARGE_INTESTINE	Teniposide →	+0.621	+2.649	.019	.046	1	1
LARGE_INTESTINE	Dactinomycin →	+0.560	+2.649	.016	.046	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

VE-822 by NIPA1 expression — LARGE_INTESTINE

Explore this box plot interactively →