NFYC

Across TCGA patient cohorts, NFYC mutation is significantly associated with the RNA expression of many other genes, with 3,142 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFYC-associated genes across cancer lineages are TXNP4, SSX2B, and MBD3L3. Each is linked with NFYC in more than 1 cancer types. Because this analysis shows association rather than direction, both NFYC-to-partner and partner-to-NFYC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXNP4 grouped by NFYC-low versus NFYC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFYC→partner) and Y-score (partner→NFYC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TXNP4 →	+0.553	+2.148	<.001	<.001	3	2
LIHC	SSX2B →	+0.213	+3.870	<.001	.004	3	2
LUAD	MBD3L3 →	+0.046	+4.786	<.001	.003	3	2
UCEC	COX15 →	+0.375	+2.230	.002	.006	3	2
UCEC	CHAF1B →	+0.693	+3.000	<.001	<.001	3	2
UCEC	BOLA3 →	+0.398	+2.807	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,142 associations by consensus.

TXNP4 by NFYC expression — UCEC

Explore this box plot interactively →