NFYC

Across TCGA pan-cancer cohorts, NFYC RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of NFYC’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NFYC RNA is repressed in tumor relative to normal tissue. In most cancer types NFYC is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and KICH are the cancer types where NFYC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NFYC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.805	<.001	11	view →
LIHC	Female	II,III,IV	+0.964	<.001	9	view →
KICH	Male	All	−0.790	<.001	7	view →
HNSC	All	All	+0.308	.002	7	view →
STAD	All	II,III,IV	+0.533	<.001	6	view →
BLCA	Female	III,IV	+0.422	.006	5	view →
CHOL	All	All	+1.431	<.001	3	view →
KIRP	All	All	−0.275	.008	2	view →
LUSC	All	All	+0.256	.003	2	view →
KIRC	Female	All	+0.182	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

NFYC–THCA

Open the THCA breakdown →