NFYC

Across TCGA pan-cancer cohorts, NFYC RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated NFYC data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher NFYC RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NFYC expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.

ACC, KICH, and LIHC are the cancer types where NFYC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.183	0.690	<.001	93	view →
KICH	OS	Quartile	All	0.314	0.947	.002	82	view →
LIHC	OS	Median	All	0.709	0.838	<.001	58	view →
UCS	DFS	Quartile	II,III,IV	0.628	0.145	.008	56	view →
LGG	OS	Median	All	0.343	0.590	<.001	52	view →
KIRC	OS	Median	All	0.707	0.561	<.001	25	view →
UCEC	OS	Quartile	All	0.810	0.901	.014	22	view →
GBM	DFS	Median	All	0.377	0.191	.002	18	view →
STAD	DFS	Median	IV	0.182	0.534	.012	15	view →
THCA	DFS	Quartile	All	0.968	0.881	.009	13	view →
DLBC	DFS	Median	All	0.662	1.000	.030	10	view →
KIRP	OS	Median	II,III,IV	0.798	0.301	.028	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

NFYC–ACC (DFS)

Open the ACC breakdown →