NFKBID

Across TCGA patient cohorts, NFKBID mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFKBID-associated genes across cancer lineages are GAPDH, PDCD4, and C-Raf_pS338. Each is linked with NFKBID in more than 1 cancer types. Because this analysis shows association rather than direction, both NFKBID-to-partner and partner-to-NFKBID results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by NFKBID-low versus NFKBID-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFKBID→partner) and Y-score (partner→NFKBID) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.594	+2.584	.005	.010	3	2
UCEC	PDCD4 →	-0.477	-2.999	.011	.035	3	2
UCEC	C-Raf_pS338 →	-0.093	-2.535	.004	.011	3	2
UCEC	eEF2 →	+0.353	+1.906	.014	.016	3	1
UCEC	A-Raf_pS299 →	-0.131	-2.321	.006	.033	3	1
UCEC	JNK2 →	+0.367	+3.710	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

GAPDH by NFKBID expression — UCEC

Explore this box plot interactively →