NFKB1

Across TCGA cell cohorts, NFKB1 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NFKB1-associated genes across cancer lineages are GH1, OR11L1, and ANGPTL5. Each is linked with NFKB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NFKB1-to-partner and partner-to-NFKB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GH1 grouped by NFKB1-low versus NFKB1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFKB1→partner) and Y-score (partner→NFKB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GH1 →	+0.041	+4.415	<.001	.007	3	1
CNS	OR11L1 →	+0.025	+4.981	<.001	.008	3	1
STOMACH	ANGPTL5 →	+0.131	+3.632	<.001	.009	3	1
LARGE_INTESTINE	PLVAP →	+0.193	+3.291	.002	.008	3	1
LARGE_INTESTINE	KLHDC7B →	+0.859	+3.444	<.001	.003	3	1
LARGE_INTESTINE	OR2C1 →	+0.119	+3.047	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

GH1 by NFKB1 expression — SKIN

Explore this box plot interactively →