NFIA-AS1

Across TCGA pan-cancer cohorts, NFIA-AS1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated NFIA-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher NFIA-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated NFIA-AS1 expression acts as an unfavorable survival marker, although some lineages such as ACC and UCS show a favorable association.

ACC, KICH, and READ are the cancer types where NFIA-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.780	0.397	<.001	98	view →
KICH	OS	Tertile	III,IV	0.184	1.000	.002	91	view →
READ	DFS	Tertile	II,III,IV	0.618	0.872	.003	52	view →
UCS	DFS	Tertile	III,IV	0.613	0.176	<.001	50	view →
UCEC	DFS	Quartile	All	0.770	0.861	.007	36	view →
UVM	OS	Tertile	III,IV	0.270	0.704	.024	27	view →
BRCA	OS	Median	All	0.635	0.519	.010	17	view →
LUAD	DFS	Tertile	IV	0.616	0.976	.045	12	view →
THYM	OS	Quartile	All	0.618	0.981	.001	11	view →
CHOL	OS	Quartile	III,IV	0.136	0.799	.017	9	view →
OV	OS	Median	III,IV	0.788	0.878	.022	8	view →
ESCA	OS	Median	III,IV	0.552	0.336	.033	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

NFIA-AS1–ACC (DFS)

Open the ACC breakdown →