NFIA-AS1

Across TCGA pan-cancer cohorts, NFIA-AS1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of NFIA-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NFIA-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NFIA-AS1 is over-expressed in tumor, although a few such as THCA and HNSC show the opposite, repressed pattern.

KIRC, THCA, and BRCA are the cancer types where NFIA-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NFIA-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.242	<.001	12	view →
THCA	All	IV	−0.492	<.001	10	view →
BRCA	All	IV	+0.334	.046	4	view →
HNSC	Female	IV	−0.078	.011	2	view →
KICH	All	IV	+0.375	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

NFIA-AS1–KIRC

Open the KIRC breakdown →