NFATC4

Across TCGA patient cohorts, NFATC4 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFATC4-associated genes across cancer lineages are EGFR_pY1068, CDK1, and MAPK_pT202_Y204. Each is linked with NFATC4 in more than 3 cancer types. Because this analysis shows association rather than direction, both NFATC4-to-partner and partner-to-NFATC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by NFATC4-low versus NFATC4-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFATC4→partner) and Y-score (partner→NFATC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EGFR_pY1068 →	+0.669	+2.814	.009	.037	3	4
UCEC	CDK1 →	+0.122	+1.820	.012	.014	3	3
STAD	MAPK_pT202_Y204 →	-0.363	-3.000	.024	.034	3	2
STAD	ASNS →	+0.458	+3.000	.013	.033	3	2
UCEC	4E-BP1 →	+0.350	+2.321	<.001	.005	3	2
UCEC	Cyclin-B1 →	+0.642	+2.999	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

EGFR_pY1068 by NFATC4 expression — BRCA

Explore this box plot interactively →