NFATC4

Across TCGA pan-cancer cohorts, NFATC4 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated NFATC4 data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher NFATC4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NFATC4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

UVM, ACC, and LGG are the cancer types where NFATC4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.377	0.823	<.001	126	view →
ACC	DFS	Median	All	0.412	0.747	<.001	56	view →
LGG	DFS	Median	All	0.310	0.481	<.001	48	view →
HNSC	DFS	Quartile	II,III,IV	0.443	0.234	.002	34	view →
THCA	DFS	Median	All	0.860	0.930	.003	32	view →
COAD	OS	Quartile	All	0.445	0.872	<.001	25	view →
KIRC	DFS	Quartile	II,III,IV	0.368	0.628	.005	17	view →
READ	OS	Median	III,IV	0.472	0.914	.017	16	view →
BRCA	DFS	Median	IV	0.490	0.187	.015	10	view →
SKCM	OS	Tertile	All	0.287	0.394	.010	9	view →
SCLC	OS	Tertile	III,IV	0.753	0.401	.023	9	view →
LIHC	OS	Quartile	II,III,IV	0.259	0.661	.004	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

NFATC4–UVM (DFS)

Open the UVM breakdown →