NFATC4

Across TCGA pan-cancer cohorts, NFATC4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of NFATC4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where NFATC4 RNA is repressed in tumor relative to normal tissue. In most cancer types NFATC4 is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, LIHC, and THCA are the cancer types where NFATC4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NFATC4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.640	<.001	11	view →
LIHC	Female	All	+1.245	<.001	9	view →
THCA	Male	III,IV	+1.145	<.001	9	view →
BLCA	Male	III,IV	−2.270	<.001	8	view →
LUAD	Female	II,III,IV	+0.781	<.001	7	view →
UCEC	All	All	−1.114	<.001	6	view →
CHOL	Female	All	+2.110	<.001	3	view →
HNSC	All	All	+0.445	.021	3	view →
STAD	Female	All	−1.122	.025	2	view →
PRAD	All	All	−0.844	<.001	2	view →
KIRP	All	All	−0.719	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

NFATC4–KICH

Open the KICH breakdown →