NFATC2IP

Across TCGA patient cohorts, NFATC2IP mutation is significantly associated with the RNA expression of many other genes, with 350 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFATC2IP-associated genes across cancer lineages are KRTAP9-2, RPL23AP45, and MIR6515. Each is linked with NFATC2IP in more than 1 cancer types. Because this analysis shows association rather than direction, both NFATC2IP-to-partner and partner-to-NFATC2IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP9-2 grouped by NFATC2IP-low versus NFATC2IP-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFATC2IP→partner) and Y-score (partner→NFATC2IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KRTAP9-2 →	+0.039	+5.401	<.001	.001	3	2
SKCM	RPL23AP45 →	+0.098	+5.097	<.001	.008	3	2
BRCA	MIR6515 →	+0.717	+8.055	<.001	.007	3	1
UCEC	TEX30 →	+0.817	+3.459	.001	.005	3	1
UCEC	NCAPD3 →	+0.812	+3.470	.001	.003	3	1
UCEC	WHAMM →	+0.614	+3.386	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 350 associations by consensus.

KRTAP9-2 by NFATC2IP expression — HNSC

Explore this box plot interactively →