NFATC2IP

Across TCGA pan-cancer cohorts, NFATC2IP RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NFATC2IP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NFATC2IP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NFATC2IP is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where NFATC2IP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NFATC2IP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.851	<.001	12	view →
KIRC	Female	All	+0.492	<.001	11	view →
LIHC	Female	II,III,IV	+0.997	<.001	9	view →
KIRP	All	IV	+0.942	<.001	9	view →
BLCA	All	All	+0.387	.001	8	view →
STAD	All	II,III,IV	+0.902	<.001	7	view →
CHOL	Male	All	+2.210	<.001	5	view →
COAD	Male	II,III,IV	+0.412	<.001	5	view →
LUSC	All	All	+0.336	<.001	4	view →
BRCA	All	II,III,IV	+0.308	<.001	4	view →
ESCA	All	All	+0.707	.010	2	view →
LUAD	All	All	+0.168	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NFATC2IP–HNSC

Open the HNSC breakdown →