NFATC2IP

Across TCGA pan-cancer cohorts, NFATC2IP RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated NFATC2IP data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher NFATC2IP RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NFATC2IP expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCS show a favorable association.

ACC, COAD, and LGG are the cancer types where NFATC2IP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.268	0.635	<.001	83	view →
COAD	DFS	Median	All	0.596	0.774	.001	44	view →
LGG	OS	Tertile	All	0.314	0.584	<.001	41	view →
UVM	DFS	Quartile	III,IV	0.182	0.892	.001	40	view →
LIHC	OS	Median	All	0.704	0.853	<.001	38	view →
LUSC	DFS	Median	III,IV	0.373	0.890	.002	36	view →
KIRC	DFS	Median	II,III,IV	0.372	0.655	<.001	35	view →
SKCM	DFS	Median	III,IV	0.689	0.501	.004	25	view →
UCS	DFS	Tertile	IV	0.932	0.361	.024	24	view →
MESO	DFS	Tertile	IV	0.135	0.545	.006	18	view →
THCA	DFS	Median	IV	0.492	0.753	.038	16	view →
THYM	OS	Tertile	All	1.000	0.694	.002	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

NFATC2IP–ACC (DFS)

Open the ACC breakdown →