NFATC2IP

Across TCGA patient cohorts, NFATC2IP mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFATC2IP-associated genes across cancer lineages are ERK2, STAT3_pY705, and INPP4B. Each is linked with NFATC2IP in more than 1 cancer types. Because this analysis shows association rather than direction, both NFATC2IP-to-partner and partner-to-NFATC2IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by NFATC2IP-low versus NFATC2IP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFATC2IP→partner) and Y-score (partner→NFATC2IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.241	+3.169	.022	.020	3	1
UCEC	STAT3_pY705 →	-0.495	-3.169	<.001	.020	3	1
UCEC	INPP4B →	-0.402	-3.156	.023	.020	2	1
UCEC	MEK1 →	+0.501	+3.169	.012	.020	2	1
UCEC	ATM →	-0.706	-3.169	.004	.020	2	1
UCEC	beta-Catenin →	+0.616	+3.000	.026	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ERK2 by NFATC2IP expression — UCEC

Explore this box plot interactively →