Across TCGA patient cohorts, NF2 mutation is significantly associated with the RNA expression of many other genes, with 1,448 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NF2-associated genes across cancer lineages are TRAJ43, MIR33B, and SLAMF8. Each is linked with NF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NF2-to-partner and partner-to-NF2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NF2→partner) and Y-score (partner→NF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAJ43 →	+0.479	+1.626	<.001	.007	3	3
COAD	MIR33B →	+0.873	+3.142	<.001	.004	3	3
UCEC	SLAMF8 →	+0.865	+4.016	<.001	<.001	3	3
SKCM	KATNBL1P3 →	+0.035	+2.592	.004	.005	3	3
LIHC	RNU6-1177P →	+0.351	+6.008	<.001	.002	3	2
MESO	MIR1301 →	+0.279	+2.584	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,448 associations by consensus.

Exploration

NF2 survival (RNA) · tumor vs normal (RNA) · all NF2 data types