NEXMIF

Across TCGA patient cohorts, NEXMIF mutation is significantly associated with the RNA expression of many other genes, with 8,628 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEXMIF-associated genes across cancer lineages are TROAP, RTRAF, and CDCA3. Each is linked with NEXMIF in more than 4 cancer types. Because this analysis shows association rather than direction, both NEXMIF-to-partner and partner-to-NEXMIF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TROAP grouped by NEXMIF-low versus NEXMIF-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEXMIF→partner) and Y-score (partner→NEXMIF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TROAP →	+0.792	+2.736	.002	<.001	3	5
STAD	RTRAF →	+0.270	+2.618	.004	.004	3	5
UCEC	CDCA3 →	+0.287	+1.676	.008	.001	3	5
LUAD	C12orf65 →	+0.319	+2.348	.001	.003	3	5
LUAD	AURKB →	+0.806	+2.240	.002	.005	3	5
UCEC	PARPBP →	+0.422	+1.440	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,628 associations by consensus.

TROAP by NEXMIF expression — LUAD

Explore this box plot interactively →