NEXMIF

Across TCGA pan-cancer cohorts, NEXMIF RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NEXMIF’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NEXMIF RNA is repressed in tumor relative to normal tissue. In most cancer types NEXMIF is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and KICH are the cancer types where NEXMIF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NEXMIF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−1.319	<.001	12	view →
COAD	Male	II,III,IV	−0.657	<.001	12	view →
KICH	All	III,IV	−1.030	<.001	10	view →
THCA	Male	III,IV	−0.868	<.001	10	view →
BLCA	Male	IV	−0.862	<.001	10	view →
STAD	All	All	−0.698	<.001	9	view →
KIRP	Male	All	−1.018	<.001	7	view →
BRCA	Female	II,III,IV	+0.304	<.001	6	view →
READ	Female	All	−1.036	<.001	5	view →
HNSC	Female	All	−0.268	.008	3	view →
ESCA	All	All	−0.868	.017	2	view →
LUSC	Male	III,IV	−0.365	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NEXMIF–KIRC

Open the KIRC breakdown →