NEXMIF

Across TCGA cell cohorts, NEXMIF mutation is significantly associated with the RNA expression of many other genes, with 390 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NEXMIF-associated genes across cancer lineages are FBXO25, SEPSECS, and ABCB7. Each is linked with NEXMIF in more than 2 cancer types. Because this analysis shows association rather than direction, both NEXMIF-to-partner and partner-to-NEXMIF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXO25 grouped by NEXMIF-low versus NEXMIF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEXMIF→partner) and Y-score (partner→NEXMIF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FBXO25 →	+0.872	+2.265	<.001	.001	3	3
LARGE_INTESTINE	SEPSECS →	+0.708	+3.459	<.001	.001	3	2
LARGE_INTESTINE	ABCB7 →	+0.418	+3.169	.007	.006	3	2
LARGE_INTESTINE	GRSF1 →	+0.480	+2.404	<.001	.004	3	2
LARGE_INTESTINE	TRMT10A →	+0.629	+3.252	<.001	.002	3	2
LARGE_INTESTINE	DCK →	+0.461	+2.265	.008	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 390 associations by consensus.

FBXO25 by NEXMIF expression — LARGE_INTESTINE

Explore this box plot interactively →