NEK1

Across TCGA patient cohorts, NEK1 mutation is significantly associated with the RNA expression of many other genes, with 4,094 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEK1-associated genes across cancer lineages are RNA5SP509, MRPL58, and TMX2P1. Each is linked with NEK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NEK1-to-partner and partner-to-NEK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP509 grouped by NEK1-low versus NEK1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK1→partner) and Y-score (partner→NEK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP509 →	+0.395	+7.924	<.001	<.001	3	3
SKCM	MRPL58 →	+0.550	+3.245	<.001	.008	3	3
UCEC	TMX2P1 →	+0.626	+3.269	<.001	<.001	3	3
SKCM	SNW1 →	+0.759	+3.198	<.001	.009	3	2
SKCM	GLRX3 →	+0.682	+3.379	.002	.005	3	2
SKCM	MRPS7 →	+0.449	+3.208	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,094 associations by consensus.

RNA5SP509 by NEK1 expression — LUSC

Explore this box plot interactively →