NEK1

Across TCGA pan-cancer cohorts, NEK1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NEK1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NEK1 RNA is repressed in tumor relative to normal tissue. In most cancer types NEK1 is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

THCA, HNSC, and BLCA are the cancer types where NEK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NEK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.198	<.001	10	view →
HNSC	All	III,IV	+0.578	<.001	9	view →
BLCA	Male	All	−1.041	<.001	8	view →
COAD	All	All	−0.357	.005	5	view →
LIHC	All	All	+0.336	<.001	5	view →
UCEC	All	All	−1.086	<.001	4	view →
BRCA	Female	All	−0.215	.004	4	view →
READ	Female	All	−1.128	.005	2	view →
CHOL	All	All	+0.726	.003	2	view →
LUAD	Female	II,III,IV	−0.424	.016	2	view →
STAD	All	IV	+0.556	.042	1	view →
KICH	All	All	−0.459	.010	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NEK1–THCA

Open the THCA breakdown →