NEFH

Across TCGA cell cohorts, NEFH mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NEFH-associated genes across cancer lineages are LILRA1, SIGLEC8, and ZAN. Each is linked with NEFH in more than 1 cancer types. Because this analysis shows association rather than direction, both NEFH-to-partner and partner-to-NEFH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LILRA1 grouped by NEFH-low versus NEFH-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEFH→partner) and Y-score (partner→NEFH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LILRA1 →	+0.113	+4.930	<.001	.008	3	1
SOFT_TISSUE	SIGLEC8 →	+0.196	+5.977	<.001	.001	3	1
SOFT_TISSUE	ZAN →	+0.006	+5.369	<.001	.004	3	1
SOFT_TISSUE	KRTAP5-4 →	+0.028	+5.369	<.001	.004	3	1
SOFT_TISSUE	TARM1 →	+0.052	+5.369	<.001	.004	3	1
LUNG_NSCLC_LUAD	OCSTAMP →	+0.009	+3.343	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

LILRA1 by NEFH expression — SOFT_TISSUE

Explore this box plot interactively →