NEFH

Across TCGA pan-cancer cohorts, NEFH RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated NEFH data layer compared with 6 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher NEFH RNA is associated with better overall survival. In most high-consensus cancer types, elevated NEFH expression acts as an unfavorable survival marker, although some lineages such as BRCA and HNSC show a favorable association.

BRCA, HNSC, and KIRP are the cancer types where NEFH RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Tertile	II,III,IV	0.946	0.871	<.001	94	view →
HNSC	DFS	Quartile	All	0.424	0.188	<.001	64	view →
KIRP	DFS	Median	II,III,IV	0.168	0.855	.001	56	view →
CHOL	DFS	Median	III,IV	0.647	0.127	.006	45	view →
CESC	OS	Tertile	II,III,IV	0.785	0.383	.002	42	view →
SCLC	DFS	Tertile	III,IV	0.656	0.290	.006	40	view →
LIHC	OS	Quartile	II,III,IV	0.240	0.603	.001	28	view →
LUSC	OS	Median	III,IV	0.265	0.820	.014	19	view →
OV	OS	Median	IV	0.506	0.278	.002	16	view →
THYM	OS	Median	II,III,IV	0.952	0.595	.012	16	view →
SARC	OS	Quartile	All	0.565	0.864	<.001	13	view →
ACC	DFS	Median	II,III,IV	0.269	0.557	.015	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

NEFH–BRCA (OS)

Open the BRCA breakdown →