NEDD8

Across TCGA patient cohorts, NEDD8 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,214 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible NEDD8-associated proteins across cancer lineages are SUPT16H, STRN3, and IPO4. Each is linked with NEDD8 in more than 8 cancer types. Because this analysis shows association rather than direction, both NEDD8-to-partner and partner-to-NEDD8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NEDD8 versus SUPT16H in GBM, with a Pearson correlation of 0.31.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NEDD8→partner) and Y-score (partner→NEDD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SUPT16H →	+0.353	+0.221	<.001	<.001	3	9
BRCA	STRN3 →	+0.285	+0.386	<.001	.008	3	8
LSCC	IPO4 →	+0.470	+0.448	<.001	<.001	3	6
BRCA	CHD8_S1995 →	+0.469	+0.571	<.001	<.001	3	6
LUAD	FKBP3 →	+0.383	+0.490	<.001	<.001	3	6
CCRCC	CHD8 →	+0.450	+0.340	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,214 associations by consensus.

NEDD8 vs SUPT16H — GBM

Explore this scatter interactively →