NEDD8

Across TCGA pan-cancer cohorts, NEDD8 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated NEDD8 data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NEDD8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NEDD8 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

HNSC, UVM, and KICH are the cancer types where NEDD8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.486	0.711	<.001	129	view →
UVM	OS	Median	All	0.443	0.797	<.001	109	view →
KICH	DFS	Quartile	II,III,IV	0.419	1.000	<.001	102	view →
ACC	DFS	Median	All	0.228	0.664	<.001	85	view →
LIHC	OS	Median	All	0.604	0.797	<.001	75	view →
BLCA	DFS	Tertile	II,III,IV	0.443	0.588	.001	65	view →
PAAD	OS	Median	II,III,IV	0.483	0.671	.001	34	view →
LAML	DFS	Quartile	All	0.214	0.624	<.001	30	view →
UCS	DFS	Tertile	IV	0.403	0.942	.024	28	view →
KIRC	DFS	Quartile	All	0.691	0.472	.002	26	view →
COAD	DFS	Quartile	IV	0.253	0.643	.006	22	view →
KIRP	DFS	Tertile	IV	0.034	0.528	.010	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

NEDD8–HNSC (DFS)

Open the HNSC breakdown →