NEDD8-MDP1

Across TCGA patient cohorts, NEDD8-MDP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,514 significant associations in total. LIHC shows the largest number of these associations.

The most reproducible NEDD8-MDP1-associated GO terms across cancer lineages are Tail-anchored membrane protein insertion into ER membrane, Negative regulation of chromosome segregation, and Regulation of mitotic sister chromatid segregation. Each is linked with NEDD8-MDP1 in more than 12 cancer types. Because this analysis shows association rather than direction, both NEDD8-MDP1-to-partner and partner-to-NEDD8-MDP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tail-anchored membrane protein insertion into ER membrane grouped by NEDD8-MDP1-low versus NEDD8-MDP1-high in UVM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NEDD8-MDP1→partner) and Y-score (partner→NEDD8-MDP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	Tail-anchored membrane protein insertion into ER membrane →	+0.053	+0.172	<.001	<.001	2	13
ACC	Negative regulation of chromosome segregation →	+0.065	+0.552	.002	<.001	3	11
ACC	Regulation of mitotic sister chromatid segregation →	+0.064	+0.527	.001	<.001	2	11
ACC	Microtubule cytoskeleton organization involved in mitosis →	+0.041	+0.301	<.001	.004	3	10
ACC	Positive regulation of mitotic cell cycle phase transition →	+0.038	+0.460	<.001	<.001	3	9
ACC	Chromosome localization →	+0.046	+0.431	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,514 associations by consensus.

Tail-anchored membrane protein insertion into ER membrane by NEDD8-MDP1 expression — UVM

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