NEDD8-MDP1

Across TCGA pan-cancer cohorts, NEDD8-MDP1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of NEDD8-MDP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where NEDD8-MDP1 RNA is repressed in tumor relative to normal tissue. In most cancer types NEDD8-MDP1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and BLCA are the cancer types where NEDD8-MDP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NEDD8-MDP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−0.296	<.001	9	view →
KIRC	Male	II,III,IV	−0.110	.001	5	view →
BLCA	All	All	+0.214	.031	3	view →
KIRP	All	IV	+0.085	.021	2	view →
ESCA	All	II,III,IV	+0.075	.037	2	view →
LIHC	All	All	+0.070	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

NEDD8-MDP1–KICH

Open the KICH breakdown →